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Treatment of Uncomplicated Skin and Skin Structure Infections in the Diabetic Patient
Diabetic neuropathy can lead to the development of ulcers on the lower extremities. Prompt treatment lowers the likelihood of infection and reduces the probability that an established infection will lead to amputation. Antibiotics are selected on the basis of the suspected organism and the level of infection. Unnecessary antibiotic prophylaxis is discouraged because it increases the likelihood that bacterial resistance to the antibiotic agent will develop. Culture samples must be taken by curettage of biopsy rather than by swabbing to assure detection of pathogens.
Introduction
In the United States, foot infection is the leading cause of both diabetes-related hospitalization (1) and lower-extremity amputation. (2-4) More than 90% of cases of osteomyelitis of the foot are associated with infected foot ulcers. The American Diabetes Association estimates that almost 90,000 lower extremity amputations secondary to diabetes are performed each year. In 85% of amputations, ulceration is a pre-disposing factor. The 5-year survival rate of unilateral diabetic amputees is 50%; for bilateral amputees, the rate drops to 0%.
Lower-extremity neuropathy associated with diabetes mellitus often leads to the development of uncomplicated skin and skin structure infections (uSSSIs) (Figure 1). Untreated, uSSSIs may develop into complicated infections (Figure 2). Long-term survival of diabetic patients depends on the recognition and proper treatment of uSSSIs before they develop into more serious conditions that warrant amputation. This article focuses on the treatment of uSSSIs in diabetic patients.
Classifying the Diabetic Wound
Proper classification of the diabetic wound is essential before selecting treatment. Diabetic foot infections are divided into 4 categories of severity: non-infected, mild, moderate, and severe. (5)
Non-infected ulcers are characterized by granulation of the tissue base, shallow tract, the absence of cellulitis and pus, and normal serous drainage. The wound is likely to be contaminated or colonized by bacteria but there are no signs of infection.
Mildly infected ulcers have 2 or more manifestations of inflammation (purulence, erythema, tenderness, pain, induration, warmth) and cellulitis or erythema that extends 2 cm or less around the ulcer. The infection is restricted to skin and superficial subcutaneous tissues. This type of wound is usually local and patients have no systemic illness or other complications.
Moderately infected ulcers have one or more of the following characteristics: cellulitis greater than 2 cm; lymphangitic streaking, location beneath superficial fascia; gangrene; abscess of deep tissue; and muscle, tendon, bone, or joint involvement. The patient is metabolically stable and systemically well, although white blood cell counts or glucose levels may change and require treatment. If located in the foot or limb, wounds of this type may eventually lead to amputation.
Severely infected ulcers have the characteristics of moderate infection plus one or more additional factors–signs or symptoms of sepsis, significant metabolic imbalance, severe peripheral vascular disease, or combinations of these. Severe diabetic infections are life-threatening. In diabetic patients, uSSSIs comprise only non-infected and mildly infected wounds.
Treatment of Diabetes-Related uSSSIs
Diabetic wound treatment requires debridement, offloading, and antibiotics in that order. Antibiotics alone will not heal a diabetic wound. Debridement (Figure 3) promotes healing by creating an acute wound. By removing necrotic tissue and bacteria, debridement establishes a basis for wound healing, allows more accurate visual assessment, promotes the influx of growth factors and platelets, and reduces the level of matrix metalloproteinases (MMPs). MMPs have been shown to degrade growth factors.
Offloading the pressure causing the wound inhibits inflammatory stimuli and allows the wound to heal. Chronic inflammatory stimuli (ie, pressure and infection) delay wound healing by increasing MMPs and decreasing the entry of endogenous growth factors. The inflammatory cascade begins with the causative pressure and may continue when infecting agents are introduced. This leads to increased activity of neutrophils and macrophages, increased production of TNF-[alpha] and IL-lb, and increased MMP production.
Wound care products can be used to interrupt the inflammatory cascade (Regranex Gel, 0.01%) or reduce MMPs (Promogran) in the chronic wound environment. If infection is present, the appropriate administration of antibiotics in important. The use of prophylactic antibiotics, however, is not based on scientific data and does not accelerate healing.
Antibiotics for the Infected Ulcer
Diabetic wound infections are often not polymicrobial as was previously thought. The responsible organisms are usually Gram-positive pathogens such as Staphylococcus aureus or group B streptococci. (6-9) In diabetic ulcers, S. aureus may occur as methicillin-susceptible S. aureus (MSSA) or methicillin-resistant S. aureus (MRSA). Community-acquired MRSA is becoming more common. Isolates in mild diabetic infections are shown in Figure 4.Because virtually all strains of S. aureus found in lower extremity infections produce [beta]-lactamase, empiric treatment of suspected S. aureus infections always includes a [beta]-lactamase-stable antibiotic (eg, a cephalosporin).
Mild diabetic infections are caused most often by staphylococci and streptococci. [beta]-Lactamase-stable antibiotics are appropriate empiric choices for these infections. In moderate to severe infections, causative agents include S. aureus (MSSA or MRSA), group B streptococci, Gram-negative organisms (Pseudomonas species are still uncommon), anaerobic bacteria (Gram-positive and Gram-negative), and Enterococcus species.
More severe infections are best treated with [beta]-lactamase inhibitors (eg, ampicillin/sulbactam with or without a quinolone), clindamycin plus an agent effective against Gram-negative pathogens, broad-spectrum quinolones, or linezolid.
A Note About Culturing
Bacteria exist in wounds at 3 levels: contamination, colonization, and infection. A wound is contaminated when bacteria are present but not multiplying. In colonization, bacteria are present and multiplying. In infected wounds, bacteria are present, multiplying, and eliciting a host response.
Because all diabetic ulcers are colonized by a variety of bacterial species, cultures of superficial swabs usually reveal multiple species (10) that may or may not be pathogenic. There is little compelling evidence that this bioload inhibits wound healing.
Evidence exists that ulcers may heal without antibiotics. (11) When physicians receive positive culture results from an ulcer lacking overt signs of infection, they may nevertheless prescribe antibiotics as a supplement to standard wound therapy. This issue was addressed in a 1996 study of Chantelau and colleagues. (11) Forty-four diabetic patients with uncomplicated neuropathic foot ulcers were given
andard treatment consisting of pressure relief, daily wound cleansing, and sterile dressings. All but one ulcer was infected. Patients were randomized to receive either amoxicillin and clavulanic acid or placebo. The results indicated no significant difference in healing between the 2 groups. The authors concluded that antibiotic treatment with amoxicillin and clavulanic acid in addition to standard wound care provided no additional benefit in uncomplicated neuropathic foot ulcers of diabetic patients.
Physicians may be concerned about the medico-legal implications associated with not prescribing antibiotics when positive culture results appear on the chart of a patient with a clinically non-infected wound. If they prescribe an inappropriate antibiotic to avoid potential litigation, however, the cost of treatment will increase and the possibility of adverse events (eg, development of resistant strains) will be introduced.
If culturing is necessary, the area is first cleansed thoroughly with antiseptic (eg, Betadine) and rinsed with sterile saline or water. Of critical importance is that culture samples be taken by curette or biopsy from the ulcer base where infectious agents reside, rather than by swabbing the surface. (7,8)
Topical Antimicrobials
Although studies show the topical antimicrobials in diabetic foot ulcerations lack efficacy, most clinicians prescribe them regularly. Commonly used agents include mupirocin, silver compounds, povidone-iodine, gentamicin-triple antibiotic preparations, and fusidic acid.
Mupirocin is FDA-cleared for the treatment of impetigo and pyoderms, but is often used off label to treat ulcers because of its effectiveness against Gram-positive organisms. Silver compounds (eg, silver sulfadiazine) are broad-spectrum antimicrobials whose usage in wound healing is increasing rapidly, especially in the treatment of venous stasis ulcers. Usage of silver compounds is supported by anecdotal case studies.
In vitro culture studies suggest that povidone-iodine antiseptic may be toxic to tissue, but in vivo toxicity in wounded tissue has not been shown. Fusidic acid is a potent antistaphylococcal drug available in both topical and oral preparations. It is available only in Europe and Canada.Diabetic Skin care,Select Medical Products, Diabet-X Body Wash, FNC Medical, Diabet-x Skin Care
Conclusions
Antibiotics for d iabetic foot infections are chosen on the basis of suspected pathogens and class of infection. Since mild infections are most often caused by staphylococci and streptococci, cephalosporins are the treatment of choice for initial therapy. To optimize compliance, antibiotic dosing should be as infrequent as possible, especially in patients taking multiple medications. Antibiotics should be changed or continued on the basis of culture and sensitivity test results.
Disclosure: Dr. Rich received an honorarium from Abbott Laboratories for her presentation.
References
1. Smith DM, Weinberger M, Katz BP. Predicting non-elective hospitalization: a model based on risk factors associated with diabetes mellitus. J Gen Intern Med. 1987;2:168-173.
2. Lipsky BA. Infectious problems of the foot in diabetic patients. In: Bowker JH, Pfeifer MA, eds. The Diabetic Foot. 6th ed. St. Louis, Mo; Mosby; 2001:467-480.
3. Reiber GE. Epidemiology of foot ulcers and amputations in the diabetic foot. In: Bowker JH, Pfeifer MA, eds. The Diabetic Foot. 6th ed. St. Louis, Mo; Mosby; 2001:13-32.
4. Currie CJ, Morgan CL, Peters JR. The epidemiology and cost of inpatient care for peripheral vascular disease, infection, neuropathy, and ulceration in diabetes. Diabetes Care. 1998;21:42-48.
5. Lipsky BA, Berendt AR, Deery HG, et al. Diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2004;39:885-910.
6. Jones EW, Edwards R, Finch R, et al. A microbiologic study of diabetic foot lesions. Diabetic Med. 1984;2:213-215.
7. Lipsky BA, Pecoraro RE, Wheat LJ. The diabetic foot. Soft tissue and bone infection. Infect Dis Clin North Am. 1990;4:409-432.
8. Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW. Assessment and management of foot disease in patients with diabetes. N Engl J Med. 1994;331:854-860.
9. Armstrong DG, Liswood PJ, Todd WF. 1995 William J. Stickel Bronze Award. Prevalence of mixed infections in the diabetic pedal wound. A retrospective review of 112 infections. J Am Podiatr Med Assoc. 1995;85:533-537.
10. Louie TJ, Bartlett JG, Tally FP, Gorbach SL. Aerobic and anaerobic bacteria in diabetic foot ulcers. Ann Intern Med. 1976;85:461-463.
11. Chantelau E, Tanudjaja T, Altenhofer F, Ersanli Z, Lacigova S, Metzger C. Antibiotic treatment for uncomplicated neuropathic forefoot ulcers in diabetes: a controlled trial. Diabet Med. 1996;13:156-159.
About the Author
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PROMOGRAN PRISMA MATRIX WOUND MANAGEMENT 28cm/4.34″ MA028 BY SYSTAGENIX $85.00 |
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(LOT OF 10) PROMOGRAN MATRIX WOUND DRESSING PG004 ~ FREE SHIPPING $49.00 |
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J & J Promogran® Matrix Wound Dressings (4.34 in sq) New Box of (10) PG004 $99.00 |
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Promogran Prisma Matrix Wound Dressing – 4.34 sq. in. This dressing has unique formulation of 55% collagen, 44% oxidized regenerated cellulose (ORC) and 1% silver-ORC. It delivers a balanced combination for protection and growth that is appropriate for a variety of wound types and conditions. Silver-ORC contains 0.25% ionically bound silver…. |
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PROMOGRAN PRISMA Matrix 4.34 in² QTY: 1 $15.21 Designed to provide protection and growth by addressing the continuous changes in the wound microenvironment. The unique combination of 55% collagen, 44% ORC and 1% silver-ORC absorbs destructive components of chronic wound fluid and creates the optimal environment for cellular growth…. |
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PROMOGRAN PRISMA Matrix Wound Dressing by Johnson and Johnson – Pad Size – 4.34 Sq inches Box of 10 – JNJMA028JNJMA028_bx $143.60 PROMOGRAN PRISMA Matrix 4.34 Sq inches… |
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J&J Promogran Matrix Wound Dressing – 4.1sq. in, Each dressing $14.53 Promogran Wound Dressing is an ORC/collagen matrix dressing that provides an environment which attributes cells and supports tissue growth. Promogran is used to treat a variety of ulcers and wounds. Promogran treats the wound by transforming into a soft, comfortable gel over the entire wound bed. Promogran should only be used when visible signs of infection present in wound area and the underlying… |
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The Matrix Reloaded – Subtitle $14.99 After creating an international sensation with the visually dazzling and intellectually challenging sci-fi blockbuster The Matrix, the Wachowski brothers returned with the first of two projected sequels that pick up where the first film left off. Neo (Keanu Reeves) and Trinity (Carrie-Anne Moss) have been summoned by Morpheus (Laurence Fishburne) to join him on a voyage to Zion, the last outpost of free human beings on Earth. Neo and Trinity’s work together has been complicated by the fact the two are involved in a serious romantic relationship. Upon their arrival in Zion, Morpheus locks horns with rival Commander Lock (Harry J. Lennix) and encounters his old flame Niobe (Jada Pinkett Smith). Meanwhile, Agent Smith (Hugo Weaving) has returned with some surprises for Neo, most notably the ability to replicate himself as many times as he pleases. Neo makes his way to The Oracle (Gloria Foster), who informs him that if he wishes to save humankind, he must unlock “The Source,” which means having to release The Key Maker (Randall Duk Kim) from the clutches of Merovingian (Lambert Wilson). While Merovingian refuses to cooperate, his wife, Persephone (Monica Bellucci), angry at her husband’s dalliances with other women, offers to help, but only in exchange for a taste of Neo’s affections. With The Keymaker in tow, Neo, Trinity, and Morpheus are chased by Merovingian’s henchmen: a pair of deadly albino twins (Neil Rayment and Adrian Rayment). Filmed primarily in Australia and California (the extended chase scene was shot on a stretch of highway build specifically for the production outside of San Francisco), The Matrix Reloaded was produced in tandem with the third film in the series, The Matrix Revolutions. ~ Mark Deming, Rovi |
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The Matrix Revolutions – Widescreen Dubbed Subtitle AC3 $5.99 Shot back-to-back with The Matrix Reloaded, the third and final installment of Andy Wachowski and Larry Wachowski’s sci-fi action saga picks up where the second film left off. Neo (Keanu Reeves) remains unconscious in the real world, caught in a mysterious subway station that lies between the machine world and the Matrix, and Bane (Ian Bliss) is still a conduit for Agent Smith (Hugo Weaving), who continues to grow out of control, threatening to destroy both worlds. Meanwhile, as the sentinels get closer and closer to Zion, the citizens of the earth’s last inhabited city prepare for the inevitable onslaught. By bargaining with The Merovingian (Lambert Wilson), Trinity (Carrie-Anne Moss) and Morpheus (Laurence Fishburne) are able to free Neo who, after meeting with The Oracle (Mary Alice stepping in for the late Gloria Foster), decides that he must leave Zion and head for the machine mainframe. As Neo and Trinity venture into the dangerous machine world, with hopes of stopping both the machines and Agent Smith, their comrades in Zion attempt to fight off the attacking sentinels with the odds stacked greatly against them. Other cast members returning include Monica Bellucci, Ngai Sing, and Harold Perrineau Jr. ~ Matthew Tobey, Rovi |
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The Matrix Reloaded – Widescreen Dubbed Subtitle Dolby $9.99 After creating an international sensation with the visually dazzling and intellectually challenging sci-fi blockbuster The Matrix, the Wachowski brothers returned with the first of two projected sequels that pick up where the first film left off. Neo (Keanu Reeves) and Trinity (Carrie-Anne Moss) have been summoned by Morpheus (Laurence Fishburne) to join him on a voyage to Zion, the last outpost of free human beings on Earth. Neo and Trinity’s work together has been complicated by the fact the two are involved in a serious romantic relationship. Upon their arrival in Zion, Morpheus locks horns with rival Commander Lock (Harry J. Lennix) and encounters his old flame Niobe (Jada Pinkett Smith). Meanwhile, Agent Smith (Hugo Weaving) has returned with some surprises for Neo, most notably the ability to replicate himself as many times as he pleases. Neo makes his way to The Oracle (Gloria Foster), who informs him that if he wishes to save humankind, he must unlock “The Source,” which means having to release The Key Maker (Randall Duk Kim) from the clutches of Merovingian (Lambert Wilson). While Merovingian refuses to cooperate, his wife, Persephone (Monica Bellucci), angry at her husband’s dalliances with other women, offers to help, but only in exchange for a taste of Neo’s affections. With The Keymaker in tow, Neo, Trinity, and Morpheus are chased by Merovingian’s henchmen: a pair of deadly albino twins (Neil Rayment and Adrian Rayment). Filmed primarily in Australia and California (the extended chase scene was shot on a stretch of highway build specifically for the production outside of San Francisco), The Matrix Reloaded was produced in tandem with the third film in the series, The Matrix Revolutions. ~ Mark Deming, Rovi |
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Kathy Smith: Matrix Method – Power Walk for Weight Loss - $5.99 Kathy Smith: Matrix Method – Power Walk for Weight Loss features the workout guru leading the viewer through a walking regimen that has been designed so that, with the proper posture, the person performing the regimen can maximize the health benefits. ~ Perry Seibert, Rovi |
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Geometrix by Schonbek MC0305DAR Matrix Cylinder 1 Light Mini Pendant with Dark Sapphire Strass crystal $448.8 Modern Contempo Mini Pendant with Dark Sapphire Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 5 H 3 W |
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Geometrix by Schonbek MC0305VIO Matrix Cylinder 1 Light Mini Pendant with Violet Strass crystal $448.8 Modern Contempo Mini Pendant with Violet Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 5 H 3 W |
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Geometrix by Schonbek MC0408CIN Matrix Cylinder 1 Light Mini Pendant with Cinnabar Strass crystal $899.8 Modern Contempo Mini Pendant with Cinnabar Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 8 H 4 W |
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Geometrix by Schonbek MC0408GOL Matrix Cylinder 1 Light Mini Pendant with Golden Strass crystal $899.8 Modern Contempo Mini Pendant with Golden Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 8 H 4 W |
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Geometrix by Schonbek MC0408TRA Matrix Cylinder 1 Light Mini Pendant with Travertine Strass crystal $899.8 Modern Contempo Mini Pendant with Travertine Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 8 H 4 W |
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Geometrix by Schonbek MC0410STR Matrix Cylinder 1 Light Mini Pendant with Strawberry Fields Strass crystal $1185.8 Modern Contempo Mini Pendant with Strawberry Fields Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 10 H 4 W |
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Geometrix by Schonbek MC0510SUN Matrix Cylinder 1 Light Mini Pendant with Sundance Strass crystal $1405.8 Modern Contempo Mini Pendant with Sundance Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 10 H 5 W |
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Geometrix by Schonbek MC1605STE Matrix Cylinder 5 Light Ceiling Pendant with Steel Strass crystal $4279 Modern Contempo Ceiling Pendant with Steel Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 5 H 16 W |
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Geometrix by Schonbek MT0510ORC Matrix 1 Light Mini Pendant with Orchid Strass crystal $1471.8 Modern Contempo Mini Pendant with Orchid Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0816SAP Matrix 4 Light Ceiling Pendant with Sapphire Strass crystal $5313 Modern Contempo Ceiling Pendant with Sapphire Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 16 H 8 W 8 L |
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Geometrix by Schonbek MT0810LAU Matrix 4 Light Ceiling Pendant with Laurel Stone Strass crystal $3641 Modern Contempo Ceiling Pendant with Laurel Stone Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 8 W 8 L |
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Geometrix by Schonbek MT2405AQU Matrix 4 Light Island Light with Aqua Strass crystal $3377 Modern Contempo Island Light with Aqua Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 3.5 W 24.5 L |
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Geometrix by Schonbek MT4805POM Matrix 8 Light Island Light with Pomegranate Strass crystal $6435 Modern Contempo Island Light with Pomegranate Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 3.5 W 48 L |
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Geometrix by Schonbek MTW0510CIN Matrix 1 Light Wall Sconce with Cinnabar Strass crystal $1097.8 Modern Contempo Wall Sconce with Cinnabar Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 5 W |
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Geometrix by Schonbek MTW0510SAP Matrix 1 Light Wall Sconce with Sapphire Strass crystal $1097.8 Modern Contempo Wall Sconce with Sapphire Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 5 W |
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Geometrix by Schonbek MTW0510VIO Matrix 1 Light Wall Sconce with Violet Strass crystal $1097.8 Modern Contempo Wall Sconce with Violet Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 5 W |
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Geometrix by Schonbek MTW0606CHI Matrix 1 Light Wall Sconce with Chinchilla Strass crystal $580.8 Modern Contempo Wall Sconce with Chinchilla Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 6 H 6 W |
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Geometrix by Schonbek MTW2405SAG Matrix 4 Light Bath Vanity Light with Sage Strass crystal $2153.8 Modern Contempo Bath Vanity Light with Sage Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 24.5 W |
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Geometrix by Schonbek MTW2405SAP Matrix 4 Light Bath Vanity Light with Sapphire Strass crystal $2153.8 Modern Contempo Bath Vanity Light with Sapphire Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 24.5 W |
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Geometrix by Schonbek MTW3605OCE Matrix 6 Light Bath Vanity Light with Ocelot Strass crystal $3465 Modern Contempo Bath Vanity Light with Ocelot Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 35.5 W |
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Monte Carlo 5MMR54RBD Matrix 2+4 Light 5 Blade Ceiling Fan in Roman Bronze $439 Modern Contempo Ceiling Fan in Roman Bronze with Matte Opal glass from the Matrix Collection by Monte Carlo. Dimensions: 18.28 H |
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Geometrix by Schonbek MC1616KAS Matrix Cylinder 8 Light Ceiling Pendant with Kashmir Strass crystal $10615 Modern Contempo Ceiling Pendant with Kashmir Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616LAU Matrix Cylinder 8 Light Ceiling Pendant with Laurel Stone Strass crystal $10615 Modern Contempo Ceiling Pendant with Laurel Stone Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616MOO Matrix Cylinder 8 Light Ceiling Pendant with Moondust Strass crystal $10615 Modern Contempo Ceiling Pendant with Moondust Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616OCE Matrix Cylinder 8 Light Ceiling Pendant with Ocelot Strass crystal $10615 Modern Contempo Ceiling Pendant with Ocelot Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616ORC Matrix Cylinder 8 Light Ceiling Pendant with Orchid Strass crystal $10615 Modern Contempo Ceiling Pendant with Orchid Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616PEA Matrix Cylinder 8 Light Ceiling Pendant with Peacock Strass crystal $10615 Modern Contempo Ceiling Pendant with Peacock Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616PLU Matrix Cylinder 8 Light Ceiling Pendant with Plum Strass crystal $10615 Modern Contempo Ceiling Pendant with Plum Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616POM Matrix Cylinder 8 Light Ceiling Pendant with Pomegranate Strass crystal $10615 Modern Contempo Ceiling Pendant with Pomegranate Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616S Matrix Cylinder 8 Light Ceiling Pendant with Clear Strass crystal $9009 Modern Contempo Ceiling Pendant with Clear Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MT0505TOR Matrix 1 Light Mini Pendant with Tortoise Shell Strass crystal $899.8 Modern Contempo Mini Pendant with Tortoise Shell Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0505TRA Matrix 1 Light Mini Pendant with Travertine Strass crystal $899.8 Modern Contempo Mini Pendant with Travertine Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0505VIN Matrix 1 Light Mini Pendant with Vintage Rose Strass crystal $899.8 Modern Contempo Mini Pendant with Vintage Rose Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0505VIO Matrix 1 Light Mini Pendant with Violet Strass crystal $899.8 Modern Contempo Mini Pendant with Violet Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0505WAT Matrix 1 Light Mini Pendant with Waterlily Strass crystal $899.8 Modern Contempo Mini Pendant with Waterlily Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 5 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0510ALA Matrix 1 Light Mini Pendant with Alabaster Strass crystal $1471.8 Modern Contempo Mini Pendant with Alabaster Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0510AQU Matrix 1 Light Mini Pendant with Aqua Strass crystal $1471.8 Modern Contempo Mini Pendant with Aqua Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0510AZU Matrix 1 Light Mini Pendant with Azurite Strass crystal $1471.8 Modern Contempo Mini Pendant with Azurite Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 4.5 W 4.5 L |
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Geometrix by Schonbek MT0510BEY Matrix 1 Light Mini Pendant with Beyond Blue Strass crystal $1471.8 Modern Contempo Mini Pendant with Beyond Blue Strass crystal from the Matrix Collection by Geometrix by Schonbek. Dimensions: 10 H 4.5 W 4.5 L |
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Geometrix by Schonbek MC1616SAG Matrix Cylinder 8 Light Ceiling Pendant with Sage Strass crystal $10615 Modern Contempo Ceiling Pendant with Sage Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616SAN Matrix Cylinder 8 Light Ceiling Pendant with Santorini Strass crystal $10615 Modern Contempo Ceiling Pendant with Santorini Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616SAP Matrix Cylinder 8 Light Ceiling Pendant with Sapphire Strass crystal $10615 Modern Contempo Ceiling Pendant with Sapphire Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616SH Matrix Cylinder 8 Light Ceiling Pendant with Silver Shade Strass crystal $10615 Modern Contempo Ceiling Pendant with Silver Shade Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC1616SMO Matrix Cylinder 8 Light Ceiling Pendant with Smoke Strass crystal $10615 Modern Contempo Ceiling Pendant with Smoke Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |
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Geometrix by Schonbek MC0305VIN Matrix Cylinder 1 Light Mini Pendant with Vintage Rose Strass crystal $448.8 Modern Contempo Mini Pendant with Vintage Rose Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 5 H 3 W |
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Geometrix by Schonbek MC1616SPI Matrix Cylinder 8 Light Ceiling Pendant with Spice Strass crystal $10615 Modern Contempo Ceiling Pendant with Spice Strass crystal from the Matrix Cylinder Collection by Geometrix by Schonbek. Dimensions: 16 H 16 W |












